منابع مشابه
A caspase homolog keeps CED-3 in check.
Apoptosis is a highly conserved form of cell death that is essential for controlling cell numbers throughout the lifetime of an organism. In Caenorhabditis elegans, the final step in the apoptotic cascade is activation of the death-inducing protease CED-3. Until now, no direct negative regulators of CED-3 had been identified, so the mechanism for maintaining a proper life-death balance was uncl...
متن کاملCaenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells
In Caenorhabditis elegans, apoptosis in germ cells is mediated by the same core apoptotic machinery that controls apoptosis in somatic cells. These include the CED-3 caspase, the CED-3 activator CED-4, and the cell death inhibitor CED-9. However, germline apoptosis also differs from somatic apoptosis in its regulation. We found that CSP-3, a caspase homolog that blocks CED-3 autoactivation and ...
متن کاملMitochondrial caspase keeps autophagy in flux
M any cellular stresses, including starvation, induce cells to up-regulate the process of auto-phagy, in which cytoplasmic content is engulfed into autophagosomes and delivered to lysosomes for degradation. Auto-phagy can promote cell homeostasis and survival by removing damaged proteins and organelles and recycling their breakdown products to enhance cell metabolism. On the other hand, autopha...
متن کاملC. elegans EIF-3.K Promotes Programmed Cell Death through CED-3 Caspase
Programmed cell death (apoptosis) is essential for the development and homeostasis of metazoans. The central step in the execution of programmed cell death is the activation of caspases. In C. elegans, the core cell death regulators EGL-1(a BH3 domain-containing protein), CED-9 (Bcl-2), and CED-4 (Apaf-1) act in an inhibitory cascade to activate the CED-3 caspase. Here we have identified an add...
متن کاملCaenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced
BACKGROUND Programmed cell death or apoptosis is a key feature of normal development, tissue homeostasis and disease progression in metazoans. Genetic studies in the nematode C. elegans have identified three key genes involved in apoptosis, ced-3, ced-4 and ced-9. Expression of ced-3 and ced-4 is required for the induction of cell death, whereas expression of ced-9 is necessary to inhibit cell ...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2009
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2008.11.003